T cell growth and function must be tightly regulated to provide protection against foreign
pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T
lymphocytes followed by a massive proliferation, subset differentiation, population …

T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …

Abstract Follicular helper CD4 T (Tfh) cells are a distinct type of differentiated CD4 T cells
uniquely specialized for B cell help. In this study, we examined Tfh cell fate commitment …

The adenosine monophosphate‐activated protein kinase (AMPK) is activated by antigen
receptor signals and energy stress in T cells. In many cell types, AMPK can maintain energy …

The regulation of lymphocyte homeostasis is critical for the development and formation of
productive immune responses. Cell numbers must be maintained to allow sufficient numbers …

The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …

Both CD4+ T cell help and IL-2 have been postulated to “program” activated CD8+ T cells for
memory cell development. However, the linkage between these two signals has not been …

Histone deacetylases (HDAC) are therapeutic targets in multiple cancers. ACY241, an
HDAC6 selective inhibitor, has shown anti-multiple myeloma (MM) activity in combination …