Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions

D Ağagündüz, F Gençer Bingöl, E Çelik… - Journal of Translational …, 2022 - Springer
Probiotics have been defined as “living microorganisms that create health benefits in the
host when taken in sufficient amounts. Recent developments in the understanding of the …

The altered anatomical distribution of ACE2 in the brain with Alzheimer's disease pathology

H Cui, S Su, Y Cao, C Ma, W Qiu - Frontiers in Cell and …, 2021 - frontiersin.org
The whole world is suffering from the coronavirus disease 2019 (COVID-19) pandemic,
induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through …

Targeting the renin-angiotensin system (RAS) for neuropsychiatric disorders

AS de Miranda, DS Macedo, NP Rocha… - Current …, 2024 - ingentaconnect.com
Background: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …

Ace2 and innate immunity in the regulation of SARS-CoV-2-induced acute lung injury: A review

L Qu, C Chen, T Yin, Q Fang, Z Hong, R Zhou… - International journal of …, 2021 - mdpi.com
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and
the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Effect of dexmedetomidine on postoperative cognitive dysfunction and the T helper 17/regulatory T cell balance in geriatric patients undergoing orthopedic …

W Zhao, J Li, J Wang, M Liu, D Yu - American Journal of …, 2023 - ncbi.nlm.nih.gov
Objectives: To investigate the effect of dexmedetomidine (DEX) on alleviating postoperative
cognitive dysfunction (POCD) and T helper 17 (Th17)/regulatory T cell (Treg) imbalance in …

Renin-angiotensin system in Huntington′ s disease: evidence from animal models and human patients

LM Kangussu, NP Rocha, PAC Valadão… - International journal of …, 2022 - mdpi.com
The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has
important functions that go beyond blood pressure regulation. Clinical and experimental …

Endogenous Vasoactive Peptides and Vascular Aging‐Related Diseases

Y Chen, Y Qi, W Lu - Oxidative Medicine and Cellular Longevity, 2022 - Wiley Online Library
Vascular aging is a specific type of organic aging that plays a central role in the morbidity
and mortality of cardiovascular and cerebrovascular diseases among the elderly. It is …

Modified levels of renin angiotensin related components in the frontal cortex and hippocampus were associated with neuroinflammation and lower neuroprotective …

NK Oliveira, EC de Brito Toscano… - Protein and Peptide …, 2022 - ingentaconnect.com
Background: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that involves
cognitive and motor dysfunctions due to hepatic failure. The clinical and experimental …

Genetic polymorphisms in the renin-angiotensin system and cognitive decline in Parkinson's disease

A Pierzchlińska, J Sławek, M Mak… - Molecular biology …, 2021 - Springer
Background Renin-angiotensin system (RAS) influences the central nervous system not only
through its peripheral impact—the brain possesses its own local RAS. Studies showed …