Physiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or
more 'real'organs (and hence require submodels of organs/tissues) and they describe …

Background Using models of respiratory compromise, loss of response to esophageal
instrumentation, and loss of responsiveness, the authors explored through simulation …

Women recover faster from propofol anaesthesia and have been described to have a higher
incidence of awareness during surgery, compared to men–an effect that may be inherent in …

Background. Predictive performance of eleven published propofol pharmacokinetic models
was evaluated for long-duration propofol infusion in children. Methods. Twenty-one aged …

Purpose. The Third Consensus Conference on the Safety of Intravenous Drug Delivery
Systems was convened to evaluate the benefits and risks of available systems and assess …

It is commonly assumed that loss of responsiveness and recovery of responsiveness occur
at similar concentrations of propofol. However, the 'conscious' and 'anaesthetised'conditions …

BACKGROUND: Propofol and remifentanil are commonly combined for total IV anesthesia.
The pharmacokinetics (PK), pharmacodynamics (PD), and drug interactions of the …

BACKGROUND: Propofol causes hypotension due to relaxation of vascular smooth muscle
cells through its direct or indirect vasodilator effects. Perivascular adipose tissue (PVAT) and …

There have been conflicting reports on whether propofol prolongs, shortens, or does not
change QT interval. The aim of this study was to determine the effect of target-controlled …

Anaesthesiologists adjust drug dosing, administration system and kind of drug to the
characteristics of the patient. They then observe the expected response and adjust dosing to …