Reaching the correct three-dimensional structure is crucial for the proper function of a
protein. The endoplasmic reticulum (ER) is the organelle where secreted and …

Pelizaeus–Merzbacher disease (PMD) is an X-linked disorder caused by mutations in the
PLP1 gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD …

Pelizaeus–Merzbacher disease (PMD) is a recessive X-linked dysmyelinating disorder of
the central nervous system (CNS). The most frequent cause of PMD is a genomic duplication …

Missense mutations in the human PLP1 gene lead to dysmyelinating diseases with a broad
range of clinical severity, ranging from severe Pelizaeus–Merzbacher disease (PMD) to …

Research in central nervous system (CNS) biology and pathology requires in vitro models,
which, to recapitulate the CNS in vivo, must have extensive myelin and synapse formation …

Duplication of PLP1, an X‐linked gene encoding the major myelin membrane protein of the
human CNS, is the most frequent cause of Pelizaeus‐Merzbacher disease (PMD) …

Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutation in the
proteolipid protein-1 (PLP1) gene, which encodes the proteolipid protein of myelinating …

Lysophosphatidic acid (LPA) is an intercellular signaling lipid that regulates multiple cellular
functions, acting through specific G-protein coupled receptors (LPA 1–6). Our previous …

In the central nervous system (CNS) the majority of axons are surrounded by a myelin
sheath, which is produced by oligodendrocytes. Myelin is a lipid‐rich insulating material that …

Differentiation of oligodendrocytes is associated with dramatic changes in plasma
membrane structure, culminating in the formation of myelin membrane sheaths. Previous …