Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

Many efforts have been put into engineering plants to improve crop yields and stress
tolerance and boost the bioproduction of valuable molecules. Yet, our capabilities are still …

The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

Synthetic biology has the potential to bring forth advanced genetic devices for applications
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …

Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA
polymerases and reshaping the biochemical landscape of gene regulation. As supercoiling …

Highlights•Environmentally responsive survival circuitry enable synthetic cell containment.•
Increased genetic stability by engineering sequence and host context.•Control circuits for …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Nucleic acid vaccines have shown promising results in the clinic against infectious diseases
and cancers. To robustly improve the vaccine efficacy and safety, we developed an …

The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …