A large number of studies during the past two decades have demonstrated the efficacy and
safety of sevoflurane across patient populations. Clinical researchers have also investigated …

General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Oesophageal atresia (EA) is a congenital abnormality of the oesophagus that is caused by
incomplete embryonic compartmentalization of the foregut. EA commonly occurs with a …

In the past 2 decades, it has become evident that individuals born with congenital heart
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …

General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …

Background Experimental evidence correlates anesthetic exposure during early
development with neuronal and glial injury and death, as well as behavioral and cognitive …

With the development of technology, more infants receive general anesthesia for surgery,
other interventions, or clinical examination at an early stage after birth. However, whether …

Background Animal studies demonstrate general anesthetic (GA) toxicity in the developing
brain. Clinical reports raise concern, but the risk of GA exposure to neurodevelopment in …

BACKGROUND Craniosynostosis is a condition in which 2 or more of the skull bones fuse
prematurely. The spectrum of the disorder most commonly involves the closure of a single …

The use of sedation and general anesthesia has facilitated the significant growth of MRI use
among children over the last years. While sedation and general anesthesia are considered …