Importance Limited studies have reported associations between anesthesia and
neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo …

Anesthetics that permit surgical procedures and stressful interventions have been found to
cause structural brain abnormalities and functional impairment in immature animals …

Disclaimer 2020: The EACTS/AEPC Guidelines represent the views of the EACTS and the
AEPC and were produced after careful consideration of the scientific and medical …

Sevoflurane, the most commonly used inhaled anesthetic in pediatric anesthesia, has been
reported to induce cognitive impairment in developing brain in preclinical and clinical …

Regional anaesthesia in children has evolved rapidly in the last decade. Although it
previously consisted of primarily neuraxial techniques, the practice now incorporates …

Agents used for the induction of anesthesia have been shown to either promote or mitigate
oxidative stress. A fine balance between the presence of reactive oxygen species (ROS) and …

All commonly used general anesthetics have been shown to cause neurotoxicity in animal
models, including nonhuman primates. Opinion, however, remains divided over how …

Volatile anesthetic agent use in the intensive care unit, aided by technological advances,
has become more accessible to critical care physicians. With increasing concern over …

Background. Experimental studies in animals have shown that exposure to general
anaesthesia in infancy can cause loss of cells in the central nervous system and long-term …

BACKGROUND: Animals exposed to anesthetics during specific age periods of brain
development experience neurotoxicity, with neurodevelopmental changes subsequently …