Background Exposure to anesthetics during early life may impair cognitive functions.
However, the underlying mechanisms remain largely unknown. We set out to determine …

Animal and human studies revealed that patterned neuronal activity is an inherent feature of
developing nervous systems. This review summarizes our current knowledge about the …

Neurodegeneration has been reported in young animals after exposure to all commonly
used general anesthetic agents. The brain may be particularly vulnerable to anesthetic …

Background. Anaesthesia can induce cognitive deficiency in young rodents and monkeys.
Mitochondrial dysfunction contributes to the anaesthesia-induced neurotoxicity and …

Objective Drug‐resistant epilepsy (DRE) during the first few months of life is challenging and
necessitates aggressive treatment, including surgery. Because the most common causes of …

Importance Approximately 23 700 US children undergo invasive mechanical ventilation for
acute respiratory failure annually, with unknown long-term effects on neurocognitive …

Background. The anaesthetic dose causing neurotoxicity in animals has been evaluated, but
the relationship between duration of volatile anaesthetic (VA) exposure and …

Previously we reported that a 5-hour exposure of 6-day-old (P6) rhesus macaques to
isoflurane triggers robust neuron and oligodendrocyte apoptosis. In an attempt to further …

Spinal anaesthesia is an established and frequently used anaesthetic technique in adults.
However, this versatile regional anaesthetic technique is less frequently used in paediatric …

Background Structural brain abnormalities in newborn animals after prolonged exposure to
all routinely used general anaesthetics have raised substantial concerns for similar effects …