Lepidopteran insects: emerging model organisms to study infection by enteropathogens

S Ahlawat, KK Sharma - Folia Microbiologica, 2023 - Springer
The in vivo analysis of a pathogen is a critical step in gaining greater knowledge of
pathogen biology and host–pathogen interactions. In the last two decades, there has been a …

Establishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection

A Dijokaite, MV Humbert, E Borkowski, RM La Ragione… - Virulence, 2021 - Taylor & Francis
Neisseria gonorrhoeae (gonococcus) causes the human sexually transmitted disease
gonorrhea. Studying gonococcal pathogenesis and developing new vaccines and therapies …

[HTML][HTML] The diarrhetic shellfish-poisoning toxin, okadaic acid, provokes gastropathy, dysbiosis and susceptibility to bacterial infection in a non-rodent bioassay …

H Emery, W Traves, AF Rowley, CJ Coates - Archives of Toxicology, 2021 - Springer
Diarrhetic shellfish-poisoning (DSP) toxins such as okadaic acid and dinophysistoxins harm
the human gastrointestinal tract, and therefore, their levels are regulated to an upper limit of …

Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv

M Asai, Y Li, J Spiropoulos, W Cooley, DJ Everest… - Virulence, 2022 - Taylor & Francis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a leading cause of
infectious disease mortality. Animal infection models have contributed substantially to our …

Virulent and necrotrophic strategies of Bacillus thuringiensis in susceptible and resistant insects, Galleria mellonella

EV Grizanova, TI Krytsyna, GV Kalmykova… - Microbial …, 2023 - Elsevier
Bacillus thuringiensis (Bt) is one of the most common entomopathogenic bacteria used as a
biopesticide, and source of endotoxin genes for generating insect-resistant transgenic …

RNAi-mediated suppression of insect metalloprotease inhibitor (IMPI) enhances Galleria mellonella susceptibility to fungal infection

EV Grizanova, CJ Coates, TM Butt… - Developmental & …, 2021 - Elsevier
The co-evolutionary arms race between disease-causing agents and their insect victims is
ancient and complex–leading to the development of specialised attack and defence …

[HTML][HTML] Effect of acute ultraviolet radiation on Galleria mellonella health and immunity

A Sabockytė, S McAllister, CJ Coates, J Lim - Journal of Invertebrate …, 2023 - Elsevier
For humans, acute and chronic overexposure to ultraviolet (UV) radiation can cause tissue
damage in the form of sunburn and promote cancer (s). The immune-modulating properties …

Nutraceutical intervention protects against bacterial and chemical-induced gastrotoxicity in a non-mammalian model, Galleria mellonella

H Emery, TM Butt, CJ Coates - Food and Chemical Toxicology, 2021 - Elsevier
Preparations of the fungus Cordyceps sinensis and bovine colostrum are considered
nutraceuticals due to their anti-inflammatory, repair and gut alimentation properties in …

[HTML][HTML] Low dose γ-radiation induced effects on wax moth (Galleria mellonella) larvae

D Copplestone, CJ Coates, J Lim - Science of the Total Environment, 2023 - Elsevier
Larvae of the greater wax moth Galleria mellonella are common pests of beehives and
commercial apiaries, and in more applied settings, these insects act as alternative in vivo …

Implant-associated biofilm infection established in an experimental Galleria mellonella model

J You, J Park, D Choi, J Yun, H Choi, IH Lee - … & Comparative Immunology, 2023 - Elsevier
The study reports in vivo biofilm infection implemented in an insect model. We mimicked
implant-associated biofilm infections in Galleria mellonella larvae using toothbrush bristles …