Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Alzheimer's disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global …

Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to
critical elements of neurodegeneration. We recently administered combined metabolic …

The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …

Nuclear magnetic resonance (NMR) spectroscopy allows for simultaneous detection of a
wide range of metabolites and lipids. As metabolites act together in complex metabolic …

Recent clinical studies have revealed that the serum levels of toxic hydrophobic bile acids
(deoxy cholic acid, lithocholic acid [LCA], and glycoursodeoxycholic acid) are significantly …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects
the elderly population. It gradually leads to memory loss, loss of thinking ability, and an …

Background Given the clinical low efficient treatment based on mono-brain-target design in
Alzheimer's disease (AD) and an increasing emphasis on microbiome-gut-brain axis which …

An easily accessible and non-invasive biomarker for the early detection of Alzheimer's
disease (AD) is needed. Evidence suggests that metabolic dysfunction underlies the …