Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy
KKW To, Z Huang, H Zhang, CR Ashby Jr, L Fu - Drug Resistance Updates, 2024 - Elsevier
Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …
An enrichment protocol and analysis pipeline for long read sequencing of the hepatitis B virus transcriptome
E Ng, MO Dobrica, JM Harris, Y Wu… - Journal of General …, 2023 - microbiologyresearch.org
Hepatitis B virus (HBV) is one of the smallest human DNA viruses and its 3.2 Kb genome
encodes multiple overlapping open reading frames, making its viral transcriptome …
encodes multiple overlapping open reading frames, making its viral transcriptome …
Decoupled degradation and translation enables noise modulation by poly (A) tails
C Grandi, M Emmaneel, FHT Nelissen… - Cell Systems, 2024 - cell.com
Poly (A) tails are crucial for mRNA translation and degradation, but the exact relationship
between tail length and mRNA kinetics remains unclear. Here, we employ a small library of …
between tail length and mRNA kinetics remains unclear. Here, we employ a small library of …
Homeostasis of mRNA concentrations through coupling transcription, export, and degradation
Q Wang, J Lin - Iscience, 2024 - cell.com
Many experiments showed that eukaryotic cells maintain a constant mRNA concentration
upon various perturbations by actively regulating mRNA production and degradation rates …
upon various perturbations by actively regulating mRNA production and degradation rates …
Searching the mechanisms of mRNA buffering: the releasing-shuttling model
Q Wang, J Lin - BioRxiv, 2023 - biorxiv.org
Many experiments showed that eukaryotic cells maintain a constant mRNA concentration
upon various perturbations by actively regulating transcription and degradation rates, known …
upon various perturbations by actively regulating transcription and degradation rates, known …
[HTML][HTML] NMD targets experience deadenylation during their maturation and endonucleolytic cleavage during their decay
MJ Viscardi, JA Arribere - bioRxiv, 2023 - ncbi.nlm.nih.gov
Premature stop codon-containing mRNAs can produce truncated and dominantly acting
proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via …
proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via …
NMD targets experience deadenylation during their maturation and endonucleolytic cleavage during their decay
JA Arribere, MJ Viscardi - bioRxiv, 2023 - biorxiv.org
Premature stop codon-containing mRNAs can produce truncated and dominantly acting
proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via …
proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via …
Alternative polyadenylation events estimation from single-cell RNA sequencing data in Schizophrenia
T Le - 2023 - aaltodoc.aalto.fi
Abstract Alternative polyadenylation (APA) in 3'untranslated region (3UTR) is a post-
transcriptional modification mechanism, which is shown to play important roles in the …
transcriptional modification mechanism, which is shown to play important roles in the …
A SHIFT IN RNA FATE: INVESTIGATING THE ROLE OF C19ORF66 DURING KSHV LYTIC REPLICATION
W Rodriguez Jr - 2023 - scholarworks.umass.edu
During viral infection, virus and host clash for control of the cell in a conflict that ultimately
drives the evolution of both sides and has lasting consequences in the form of pathogenesis …
drives the evolution of both sides and has lasting consequences in the form of pathogenesis …