Gut microbiota and microbial metabolism in early risk of cardiometabolic disease

CL Gabriel, JF Ferguson - Circulation Research, 2023 - Am Heart Assoc
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

[HTML][HTML] Methionine restriction-association with redox homeostasis and implications on aging and diseases

Y Zhang, J Jelleschitz, T Grune, W Chen, Y Zhao, M Jia… - Redox Biology, 2022 - Elsevier
Methionine is an essential amino acid, involved in the promotion of growth, immunity, and
regulation of energy metabolism. Over the decades, research has long focused on the …

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation

C Zhang, L Yu, C Ma, S Jiang, Y Zhang, S Wang… - Cell Host & Microbe, 2023 - cell.com
Impaired gastrointestinal motility is associated with gut dysbiosis. Probiotics, such as
Bifidobacteria, can improve this bowel disorder; however, efficacy is strain-dependent. We …

Microbially produced imidazole propionate is associated with heart failure and mortality

A Molinaro, I Nemet, P Bel Lassen, R Chakaroun… - Heart Failure, 2023 - jacc.org
Background Over the past years, it has become clear that the microbial ecosystem in the gut
has a profound capacity to interact with the host through the production of a wide range of …

L‐carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1‐Parkin‐dependent mitophagy through the CPT1a‐PHB2 …

S Li, M Liu, J Chen, Y Chen, M Yin, Y Zhou… - Acta …, 2023 - Wiley Online Library
Aim To explore the beneficial effects of L‐carnitine on cardiac microvascular dysfunction in
diabetic cardiomyopathy from the perspectives of mitophagy and mitochondrial integrity …

Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment

D Poursalehi, K Lotfi, P Saneei - Ageing Research Reviews, 2023 - Elsevier
Background Several studies have explored the association between Mediterranean diet and
frailty, but reported inconsistent results. This systematic review and dose-response meta …

[HTML][HTML] Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications

F Puig-Castellví, R Pacheco-Tapia, M Deslande… - TrAC Trends in …, 2023 - Elsevier
The human microbiome and its metabolic output play an important role in shaping human
health and disease. The host-microbe crosstalk is often characterised using metabolomics …

Prognostic value of gut microbe‐generated metabolite phenylacetylglutamine in patients with heart failure

WHW Tang, I Nemet, XS Li, Y Wu… - European Journal of …, 2024 - Wiley Online Library
ABSTRACT Aim Phenylacetylglutamine (PAGln) is a phenylalanine‐derived metabolite
produced by gut microbiota with mechanistic links to heart failure (HF)‐relevant phenotypes …

An integrated environmental nutrition model for dietary sustainability assessment

R Aidoo, CK Romana, EM Kwofie, JI Baum - Journal of Cleaner Production, 2023 - Elsevier
Environmental nutrition is gradually replacing the environmentally siloed sustainability
assessment models to enhance sustainable dietary decisions. However, prominent …