Background: Electronic cigarette (e-cigarette) use has increased substantially in recent
years. While e-cigarettes have been proposed as a potentially effective smoking cessation …

Background Nicotine receptor partial agonists may help people to stop smoking by a
combination of maintaining moderate levels of dopamine to counteract withdrawal …

Background Substantial variability exists in therapeutic response and adverse effects with
pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for …

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …

Substance use continues to contribute to significant morbidity and mortality in the United
States, for both women and men, more so than any other preventable health condition. To …

Introduction: Women have lower rates of quitting than men with both bupropion and nicotine
replacement. It is unknown whether varenicline demonstrates differential efficacy for men …

Introduction: Converging clinical and biological evidence suggest sex is an important factor
when selecting a pharmacological intervention for smoking cessation. The current …

Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk
for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy …

Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related
diseases, are altered by the rate of nicotine clearance. Nicotine clearance can be estimated …

Given clear evidence that smoking lowers weight, it is possible that individuals with higher
body mass index (BMI) smoke in order to lose or maintain their weight. We performed …