This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …

Introduction: Methamphetamine use is a serious public health concern in many countries
and is second to cannabis as the most widely abused illicit drug in the world. Effective …

The recent and precipitous increase in opioid analgesic abuse and overdose has inspired
investigation of the dopamine D3 receptor (D3R) as a target for therapeutic intervention …

In the search for efficacious pharmacotherapies to treat cocaine addiction much attention
has been given to agents targeting dopamine D1 or D3 receptors because of the …

Methamphetamine (METH) is a highly addictive psychostimulant. Cannabidiol (CBD) is an
exogenous cannabinoid without psychostimulating activity, which has potential therapeutic …

The main problem with addiction is a relapse with a high rate in methamphetamine (METH)
abusers. Using addictive drugs repetitively will cause the reward. METH reward is due to an …

Methamphetamine addiction causes serious public health problems worldwide. However,
there is no effective medication licensed for methamphetamine addiction. The endogenous …

Post-traumatic stress disorder (PTSD) is a complicated psychiatric disorder, which occurs
after exposure to a traumatic event. The main clinical manifestation of PTSD includes fear …

Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists
are a potential option for the treatment of drug addiction. The reinstatement of the addiction …