The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

Background Preladenant is an adenosine 2A (A 2A) receptor antagonist. In animal models
of Parkinson's disease, preladenant monotherapy improves motor function without causing …

Maternal separation (MS) is an early life stress model that induces permanent changes in
the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial …

A2A adenosine receptor antagonists usually have bi-or tricyclic N aromatic systems with
varying substitution patterns to achieve desired receptor affinity and selectivity. Using a …

Adenosine A 2A receptors are putative therapeutic targets for neurological disorders. The
adenosine A 2A receptor antagonist istradefylline is approved in Japan for Parkinson's …

The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …

Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …