Adenosine A2A Receptor as a Drug Discovery Target
M de Lera Ruiz, YH Lim, J Zheng - Journal of medicinal chemistry, 2014 - ACS Publications
The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …
extensively studied during the past few decades because it offers numerous possibilities for …
Role of adenosine in epilepsy and seizures
FC Tescarollo, DM Rombo, LK DeLiberto… - Journal of caffeine …, 2020 - liebertpub.com
Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
DG Ferreira, M Temido-Ferreira… - Nature …, 2017 - nature.com
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
[HTML][HTML] Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
M Temido-Ferreira, DG Ferreira, VL Batalha… - Molecular …, 2020 - nature.com
Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …
Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial
RA Hauser, M Cantillon, E Pourcher, F Micheli… - The Lancet …, 2011 - thelancet.com
Background Preladenant is an adenosine 2A (A 2A) receptor antagonist. In animal models
of Parkinson's disease, preladenant monotherapy improves motor function without causing …
of Parkinson's disease, preladenant monotherapy improves motor function without causing …
Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation
VL Batalha, JM Pêgo, BM Fontinha, AR Costenla… - Molecular …, 2013 - nature.com
Maternal separation (MS) is an early life stress model that induces permanent changes in
the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial …
the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial …
2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A2A Adenosine Receptor Antagonists
M Mantri, O de Graaf, J van Veldhoven… - Journal of medicinal …, 2008 - ACS Publications
A2A adenosine receptor antagonists usually have bi-or tricyclic N aromatic systems with
varying substitution patterns to achieve desired receptor affinity and selectivity. Using a …
varying substitution patterns to achieve desired receptor affinity and selectivity. Using a …
Istradefylline reduces memory deficits in aging mice with amyloid pathology
Adenosine A 2A receptors are putative therapeutic targets for neurological disorders. The
adenosine A 2A receptor antagonist istradefylline is approved in Japan for Parkinson's …
adenosine A 2A receptor antagonist istradefylline is approved in Japan for Parkinson's …
[HTML][HTML] Adenosine A2A receptors control synaptic remodeling in the adult brain
X Xu, RO Beleza, FQ Gonçalves, S Valbuena… - Scientific Reports, 2022 - nature.com
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …
History and Perspectives of A2A Adenosine Receptor Antagonists as Potential Therapeutic Agents
D Preti, PG Baraldi, AR Moorman… - Medicinal research …, 2015 - Wiley Online Library
Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …