Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

The immune system is a complex network of cells with critical functions in health and
disease. However, a comprehensive census of the cells comprising the immune system is …

Although circulating tumor DNA (ctDNA) assays are increasingly used to inform clinical
decisions in cancer care, they have limited ability to identify the transcriptional programs that …

Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated
compared with those of healthy controls, but the sources of this extra cfDNA have never …

Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs.
Deciphering the tissue origin of cfDNA can reveal abnormal cell death because of diseases …

Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …

This review delves into the rapidly evolving landscape of liquid biopsy technologies based
on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in …

Castration-resistant prostate cancer (CRPC) is a heterogeneous disease associated with
phenotypic subtypes that drive therapy response and outcome differences. Histologic …