Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

The biosynthesis of glycopeptide antibiotics such as vancomycin and other biologically
active biaryl-bridged and diaryl ether-linked macrocyclic peptides includes key enzymatic …

Research in natural products, the genetically encoded small molecules produced by
organisms in an idiosyncratic fashion, deals with molecular structure, biosynthesis, and …

Environmentally friendly and highly efficient synthesis of α-deuterated amines is achieved
via a concise electrochemical process using D2O as deuterium source without any external …

The biosynthesis of complex natural products by non-ribosomal peptide synthetases
(NRPSs) and the related polyketide synthases (PKSs) represents a major source of …

Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes
highly racemizable 3, 5-dihydroxyphenylglycines (Dpgs). Here we describe the total …

Non-ribosomal peptide biosynthesis produces highly diverse natural products through a
complex cascade of enzymatic reactions that together function with high selectivity to …