Study design This is an animal study. Objectives Metformin is a safe drug for controlling
blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after …

Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone
metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Cancer-induced bone pain (CIBP) remains a major challenge in patients suffering from bone
metastases because of the complex mechanisms and unsatisfactory treatments. Emerging …

Chronic pain is a major global health issue that affects all populations regardless of sex,
age, ethnicity/race, or country of origin, leading to persistent physical and emotional distress …

Cognitive impairment is one of the most common complications associated with chronic
pain. Almost 20% of chronic pain patients suffer from cognitive impairment, which may …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Cancer-induced bone pain is one of the most severe types of pathological pain, which often
occurs in patients with advanced prostate, breast, and lung cancer. It is of great significance …

Microglia can modulate spinal nociceptive transmission. Yet, their role in spinal cord
stimulation (SCS)-induced pain inhibition is unclear. Here, we examined how SCS affects …

BACKGROUND: Pain and depression are highly prevalent symptoms in cancer patients.
They tend to occur simultaneously and affect each other and share biological pathways and …