Background: Chemokine, monocyte chemoattractant protein-1 (MCP-1), is a potential factor
to cause cancer-induced bone pain (CIBP). NF-κB signaling is very important in mediating …

Cancer pain is one of the most common and serious symptoms of cancer patients. At
present, the agents used for the prevention or treatment of cancer pain do not act with …

Background To date, several studies have confirmed that driving forces of the inflammatory
tumour microenvironment trigger spontaneous cancer cell fusion. However, less is known …

Introduction: Bone cancer pain (BCP) remains to be a clinical challenge with limited
pharmaceutical interventions. Therefore, novel therapeutic targets for the management of …

Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients
because of our lack of understanding of its mechanisms. Previous studies have shown the …

Knee osteoarthritis (OA) pain is the most common joint pain. Currently, dysfunction in the
central nervous system rather than knee joint degeneration is considered to be the major …

Discogenic low back pain (DLBP) is a multifactorial disease and associated with
intervertebral disc degeneration. Calcitonin gene-related protein (CGRP) plays a critical role …

Inflammatory pain activates astrocytes and increases inflammatory cytokine release in the
spinal cord. Mitochondrial fusion and fission rely on the functions of dynamin-related protein …

Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and
underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence …

Bone cancer pain is common in patients with advanced cancers as tumors metastasize to
bone. Pathogenesis of bone cancer pain is complex and poorly understood which leads to …