Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)
JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …
affecting patients with cancer and patients with osteoporosis who have been treated with …
Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …
[HTML][HTML] Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB
S Gao, G Zheng, L Wang, Y Liang, S Zhang, X Lao… - PloS one, 2017 - journals.plos.org
Purpose Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of
systemic BPs administration, the mechanism of which is still unclarified. Recently, platelet …
systemic BPs administration, the mechanism of which is still unclarified. Recently, platelet …
[HTML][HTML] A model for osteonecrosis of the jaw with zoledronate treatment following repeated major trauma
RN Howie, JL Borke, Z Kurago, A Daoudi, J Cray… - PloS one, 2015 - journals.plos.org
This study aims to develop a reproducible rat model for post-traumatic bisphosphonate-
related osteonecrosis of the jaw (BRONJ). In our previous studies using dental extraction as …
related osteonecrosis of the jaw (BRONJ). In our previous studies using dental extraction as …
Zoledronic acid induces site-specific structural changes and decreases vascular area in the alveolar bone
MQS Soares, J Van Dessel, R Jacobs… - Journal of Oral and …, 2018 - Elsevier
Purpose The aim was to assess the effect of a relevant regimen of zoledronic acid (ZA)
treatment for the study of bisphosphonate-related osteonecrosis of the jaw on alveolar bone …
treatment for the study of bisphosphonate-related osteonecrosis of the jaw on alveolar bone …
Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients
N Heim, W Götz, FJ Kramer… - Dentomaxillofacial …, 2019 - academic.oup.com
Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well known side-effect
of anti-resorptive drugs. Changes in bone density might potentially constitute the …
of anti-resorptive drugs. Changes in bone density might potentially constitute the …
Medication-related osteonecrosis of the jaw in patients treated concurrently with antiresorptive and antiangiogenic agents: Systematic review and meta-analysis
A Srivastava, GMN Gonzalez, Y Geng… - Journal of …, 2021 - meridian.allenpress.com
Introduction Medication-related osteonecrosis of the jaws (MRONJ) is a known adverse
event related to the use of antiresorptive (AR) drugs. More recently, an association between …
event related to the use of antiresorptive (AR) drugs. More recently, an association between …
Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats
Á Janovszky, A Szabó, R Varga, D Garab… - Clinical oral …, 2015 - Springer
Objectives Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw
and less frequently in other bones. Because of the crucial role of periosteal perfusion in …
and less frequently in other bones. Because of the crucial role of periosteal perfusion in …
[HTML][HTML] Angiogenesis in the development of medication-related osteonecrosis of the jaws: an overview
AM Pabst, M Krüger, S Blatt, T Ziebart… - Dentistry Journal, 2016 - mdpi.com
Medication-related osteonecrosis of the jaws (MR-ONJ) is one of the most relevant side
effects of bisphosphonate therapy; it is clinically defined as a non-healing wound in …
effects of bisphosphonate therapy; it is clinically defined as a non-healing wound in …
Zoledronate induces osteonecrosis of the jaw in sheep
Introduction The treatment of bisphosphonate-related osteonecrosis of the jaw has become
routine in maxillofacial hospitals. However, the etiopathology has not yet been fully …
routine in maxillofacial hospitals. However, the etiopathology has not yet been fully …