Sex differences in neuroimmunity and pain

S Rosen, B Ham, JS Mogil - Journal of neuroscience research, 2017 - Wiley Online Library
Differences in the prevalence of chronic pain in women vs. men are well known, and
decades of laboratory experimentation have demonstrated that women are more sensitive to …

Sex differences in pain and opioid mediated antinociception: Modulatory role of gonadal hormones

SA Nasser, EA Afify - Life sciences, 2019 - Elsevier
Sex-related differences in pain and opioids has been the focus of many researches. It is
demonstrated that women experience greater clinical pain, lower pain threshold and …

Pain in parkinson s disease: a cross-sectional study of its prevalence, types, and relationship to depression and quality of life

P Valkovic, M Minar, H Singliarova, J Harsany… - PLoS …, 2015 - journals.plos.org
Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to
determine the prevalence of pain, its various types and characteristics, as well as its impact …

Transcriptomic sex differences in sensory neuronal populations of mice

J Mecklenburg, Y Zou, A Wangzhou, D Garcia, Z Lai… - Scientific reports, 2020 - nature.com
Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …

Menstruation pulls the trigger for inflammation and pain in endometriosis

A Laux-Biehlmann, T d'Hooghe, TM Zollner - Trends in pharmacological …, 2015 - cell.com
Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the
presence and growth of endometrial tissue outside the uterine cavity. It affects 5–10% of the …

Age, gender, and women's health and the patient

LA Houghton, M Heitkemper, MD Crowell, A Emmanuel… - Gastroenterology, 2016 - Elsevier
Patients with functional gastrointestinal disorders (FGIDs) often experience distress, reduced
quality of life, a perceived lack of validation, and an unsatisfactory experience with health …

Pain and sex hormones: a review of current understanding

AJ Maurer, A Lissounov, I Knezevic, KD Candido… - Pain …, 2016 - Taylor & Francis
Multiple epidemiologic studies have demonstrated an increased prevalence for women in
several chronic pain disorders. Clinical and experimental investigations have consistently …

Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans

J Lasselin, M Lekander, J Axelsson… - Frontiers in …, 2018 - Elsevier
Human models demonstrate that experimental activation of the innate immune system has
profound effects on brain activation and behavior, inducing fatigue, worsened mood and …

Modality and sex differences in pain sensitivity during human endotoxemia

B Karshikoff, M Lekander, A Soop, F Lindstedt… - Brain, behavior, and …, 2015 - Elsevier
Systemic inflammation can induce pain hypersensitivity in animal and human experimental
models, and has been proposed to be central in clinical pain conditions. Women are …

Gender specific somatic symptom burden and mortality risk in the general population

S Atasoy, C Hausteiner-Wiehle, H Sattel, H Johar… - Scientific reports, 2022 - nature.com
Gender specific all-cause mortality risk associated with a high somatic symptom burden
(SSB) in a population-based cohort was investigated. The study population included 5679 …