Everything old is new again: drug repurposing approach for non-small cell lung cancer targeting MAPK signaling pathway
Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
Precision medicine review: rare driver mutations and their biophysical classification
How can biophysical principles help precision medicine identify rare driver mutations? A
major tenet of pragmatic approaches to precision oncology and pharmacology is that driver …
major tenet of pragmatic approaches to precision oncology and pharmacology is that driver …
Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial‐mesenchymal transition induced by the TGF‐β1/H‐Ras signaling pathway
C Ma, Y Yang, L Xu, W Tu, F Chen… - Journal of Cellular …, 2020 - Wiley Online Library
Abstract Ras converting enzyme 1 (Rce1) plays an important role in invasion and metastasis
of malignancy. However, the mechanism has not yet been fully explored in hepatocellular …
of malignancy. However, the mechanism has not yet been fully explored in hepatocellular …
A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5
C Washington, R Chernet, RH Gokhale… - PLoS …, 2020 - journals.plos.org
Dysregulation of the Ras oncogene in development causes developmental disorders,“
Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues …
Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues …
[HTML][HTML] Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia
Aberrant signaling triggered by oncogenic or hyperactive RAS proteins contributes to the
malignant phenotypes in a significant percentage of myeloid malignancies. Of these …
malignant phenotypes in a significant percentage of myeloid malignancies. Of these …