Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a mutation in
the C1 esterase inhibitor gene. HAE affects 1/50,000 people worldwide. Three main types of …

We propose a model in which FXII is normally maintained in a closed conformation resistant
to activation by intramolecular interactions involving the fibronectin type-2 and kringle …

Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of
soft tissue swelling due to excessive bradykinin production. In most cases, dysregulation of …

Factor XII (FXII), the zymogen of the protease FXIIa, contributes to pathologic processes
such as bradykinin-dependent angioedema and thrombosis through its capacity to convert …

Background ACEi medications were developed after it was noted that people bitten by the
Brazilian pit viper Bothrops jararaca developed profound hypotension and frequently died …

Background Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent
episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity …

Neurologic manifestations have been occasionally described in patients with bradykinin-
mediated angioedema. The existing literature is currently limited to case series and case …

In an article published by Helvetica Chimica Acta in 1995, chemist P. Martin describes the
synthesis of 2′‐O‐alkylated ribonucleosides for use in therapeutic antisense …

Background The pathogenesis of hereditary angioedema (HAE) type I and type II is linked to
defective C1 esterase inhibitor (C1-INH) encoded by the SERPING1 gene. There are …

Advances in next generation sequencing technologies, as well as their expanded
accessibility and clinical use over the past 2 decades, have led to an exponential increase in …