Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses

SV Nyholm, J Graf - Nature Reviews Microbiology, 2012 - nature.com
The innate immune system is present in all animals and is a crucial first line of defence
against pathogens. However, animals also harbour large numbers of beneficial …

[HTML][HTML] Host matters: medicinal leech digestive-tract symbionts and their pathogenic potential

JN Marden, EA McClure, L Beka, J Graf - Frontiers in Microbiology, 2016 - frontiersin.org
Digestive-tract microbiota exert tremendous influence over host health. Host-symbiont model
systems are studied to investigate how symbioses are initiated and maintained, as well as to …

Low-level antimicrobials in the medicinal leech select for resistant pathogens that spread to patients

L Beka, MS Fullmer, SM Colston, MC Nelson… - MBio, 2018 - Am Soc Microbiol
ABSTRACT Fluoroquinolones (FQs) and ciprofloxacin (Cp) are important antimicrobials that
pollute the environment in trace amounts. Although Cp has been recommended as …

Neuro-immune lessons from an annelid: the medicinal leech

A Tasiemski, M Salzet - Developmental & Comparative Immunology, 2017 - Elsevier
An important question that remains unanswered is how the vertebrate neuroimmune system
can be both friend and foe to the damaged nervous tissue. Some of the difficulty in obtaining …

[HTML][HTML] Metagenomic analysis of the medicinal leech gut microbiota

MA Maltz, L Bomar, P Lapierre, HG Morrison… - Frontiers in …, 2014 - frontiersin.org
There are trillions of microbes found throughout the human body and they exceed the
number of eukaryotic cells by 10-fold. Metagenomic studies have revealed that the majority …

Draft genome sequence of Aeromonas veronii Hm21, a symbiotic isolate from the medicinal leech digestive tract

L Bomar, WZ Stephens, MC Nelson, K Velle… - Genome …, 2013 - Am Soc Microbiol
Aeromonas veronii strain Hm21 was isolated from the digestive tract of the medicinal leech
Hirudo verbana and has been used to identify genes that are important for host colonization …

Lessons from digestive-tract symbioses between bacteria and invertebrates

J Graf - Annual review of microbiology, 2016 - annualreviews.org
In most animals, digestive tracts harbor the greatest number of bacteria in the animal that
contribute to its health: by aiding in the digestion of nutrients, provisioning essential nutrients …

Macrobdella decora: Old World Leech Gut Microbial Community Structure Conserved in a New World Leech

EA McClure, MC Nelson, A Lin… - Applied and Environmental …, 2021 - Am Soc Microbiol
Leeches are found in terrestrial, aquatic, and marine habitats on all continents.
Sanguivorous leeches have been used in medicine for millennia. Modern scientific uses …

A tale of transmission: Aeromonas veronii activity within leech-exuded mucus

BM Ott, AM Dacks, KJ Ryan… - Applied and Environmental …, 2016 - Am Soc Microbiol
Transmission, critical to the establishment and persistence of host-associated microbiotas,
also exposes symbionts to new environmental conditions. With horizontal transmission …

RNA-Seq 技术在瘤胃微生物研究中的应用进展

廖奇, 刘旭川, 李清, 樊月圆, 张春勇, 杨舒黎, 毛华明… - 动物营养学报, 2015 - cqvip.com
反刍动物瘤胃内多种多样的微生物组成一个复杂的微生态系统, 它们在瘤胃内物质消化过程中
发挥重要作用. RNA? Seq 技术的出现为反刍动物瘤胃微生物的研究提供了前所未有的机遇 …