[HTML][HTML] Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine …
AJL Cooper, T Dorai, JT Pinto, TT Denton - Biology, 2023 - mdpi.com
Simple Summary Many types of cancer cells utilize the common amino acid l-glutamine to
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …
[HTML][HTML] BCKDK modification enhances the anticancer efficacy of CAR-T cells by reprogramming branched chain amino acid metabolism
Q Yang, X Zhu, P Huang, C Li, L Han, Y Han, R Gan… - Molecular Therapy, 2024 - cell.com
Altered branched chain amino acids (BCAAs), including leucine, isoleucine, and valine, are
frequently observed in patients with advanced cancer. We evaluated the efficacy of chimeric …
frequently observed in patients with advanced cancer. We evaluated the efficacy of chimeric …
[HTML][HTML] Metabolic remodeling by the PD-L1 inhibitor BMS-202 significantly inhibits cell malignancy in human glioblastoma
X Yang, W Wang, T Ji - Cell Death & Disease, 2024 - nature.com
Recently, crystallographic studies have demonstrated that BMS-202, a small-molecule
compound characterized by a methoxy-1-pyridine chemical structure, exhibits a high affinity …
compound characterized by a methoxy-1-pyridine chemical structure, exhibits a high affinity …