For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …

This review is an attempt to establish concepts of splicing and alternative splicing giving
proper relevance to introns, the key actors in this mechanism. It might also work as a guide …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein
expression and cellular function. However, the intricate subcellular dynamics of RNA remain …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

The spatial sorting of RNA transcripts is fundamental for the refinement of gene expression
to distinct subcellular regions. Although, in non-mammalian early embryogenesis …

Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …

Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …

Dissecting the myriad regulatory mechanisms controlling eukaryotic transcripts from
production to degradation requires quantitative measurements of mRNA flow across the cell …

Highly multiplexed imaging holds enormous promise for understanding how spatial context
shapes the activity of the genome and its products at multiple length scales. Here, we …