Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

The RASopathies are a group of disorders caused by a germline mutation in one of the
genes encoding a component of the RAS/MAPK pathway. These disorders, including …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric SHP2
inhibitors (SHP2i) in the clinic prevent SHP2 activation, block proliferation of RTK-or cycling …

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability
(MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy …

Proteolysis targeting chimeras (PROTACs), which hijack proteins of interest (POIs) and
recruit E3 ligases for target degradation via the ubiquitin-proteasome pathway, are a novel …