Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance

AM Khalaf, D Fuentes, AI Morshid… - Journal of …, 2018 - Taylor & Francis
Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies
and one of the fastest-growing causes of cancer-related mortality in the United States. The …

[HTML][HTML] HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

J Torresi, BM Tran, D Christiansen, L Earnest-Silveira… - Bmc Cancer, 2019 - Springer
Abstract Background Hepatitis B virus (HBV) is the leading cause of liver cancer, but the
mechanisms by which HBV causes liver cancer are poorly understood and …

[HTML][HTML] Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

W Guo, J Zhang, D Zhang, S Cao, G Li, S Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of
cancer-related mortality worldwide. Recent studies identified that circ-ITCH Suppresses …

Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short-and long-term models

HL Liu, IJ Yeh, NN Phan, YH Wu, MC Yen… - Infection, Genetics and …, 2020 - Elsevier
Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome
coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread …

[HTML][HTML] Aberrant regulation of Wnt signaling in hepatocellular carcinoma

LJ Liu, SX Xie, YT Chen, JL Xue… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the world. Several
signaling pathways, including the wingless/int-1 (Wnt) signaling pathway, have been shown …

[HTML][HTML] MiRNA-27a promotes the proliferation and invasion of human gastric cancer MGC803 cells by targeting SFRP1 via Wnt/β-catenin signaling pathway

F Wu, J Li, N Guo, XH Wang, YQ Liao - American Journal of …, 2017 - ncbi.nlm.nih.gov
This study aims to elucidate the effects of microRNA-27a (miR-27a) on the proliferation and
invasion of gastric cancer (GC) cells by targeting SFRP1 via Wnt/β-catenin signaling …

[HTML][HTML] Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal …

J Yu, Y Huang, L Liu, J Wang, J Yin, L Huang, S Chen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal
carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin …

[HTML][HTML] CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/β-catenin signaling pathway

XW Mao, JQ Xiao, G Xu, ZY Li, HF Wu, Y Li, YC Zheng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Increased expression of cullin 4B (CUL4B) is linked to progression in several cancers. This
study aims to explore the effects of CUL4B on bladder cancer (BC) metastasis and epithelial …

[HTML][HTML] The hepatitis B virus pre-core protein p22 activates Wnt signaling

BM Tran, DJ Flanagan, G Ebert, N Warner, H Tran… - Cancers, 2020 - mdpi.com
An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple
steps via various mechanisms. Infection with hepatitis B virus (HBV) is a major risk factor for …

[HTML][HTML] Deregulation of frizzled receptors in hepatocellular carcinoma

KKS Chan, RCL Lo - International Journal of Molecular Sciences, 2018 - mdpi.com
G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are
described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the …