Stenotrophomonas maltophilia is a non-fermenting, Gram-negative bacillus that has
emerged as an opportunistic nosocomial pathogen. Its intrinsic multidrug resistance makes …

Drug resistance is well-defined as a serious problem in our living world. To survive,
microbes develop defense strategies against antimicrobial drugs. Drugs exhibit less or no …

Cefiderocol is a novel siderophore cephalosporin exhibiting potent antimicrobial activities.
Although cefiderocol has not been approved in China, resistance is emerging. A multicenter …

Resistance to antimicrobials and particularly multidrug resistance is one of the greatest
challenges in the health system nowadays. The continual increase in the rates of …

Background Cefiderocol is a novel β-lactam with activity against carbapenem-resistant
Acinetobacter baumannii (CRAB), but its role in CRAB pulmonary infections is controversial …

Multidrug resistant Gram-negative bacteremia represents a therapeutic challenge clinicians
have to deal with. This concern becomes more difficult when causing germs are represented …

Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat
(DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas …

Introduction Novel last resort beta-lactam antibiotics are now available for management of
infections due to New-Delhi Metallo-Beta-Lactamase (NDM) producing Enterobacterales …

Severe/MDR Gram-negative infections continue to be important infections due to their
impact on patient outcomes, especially in critically ill and immunocompromised hosts. The …

With the rising levels of drug resistance, developing efficient antimicrobial therapies has
become a priority. A promising strategy is the conjugation of antibiotics with relevant …