Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives

S Lista, R González-Domínguez, S López-Ortiz… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10 to 25 years before the onset of clinical symptoms. As multiple functionally interconnected …

Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties

J Udagawa, K Hino - Brain research bulletin, 2022 - Elsevier
Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …

PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos

Z Yang, L Fu, M Cao, F Li, J Li, Z Chen, A Guo… - Science of The Total …, 2023 - Elsevier
Per-and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants,
posing developmental toxicity to fish and human. PFAS-induced lipid metabolism disorders …

An integrated study on the comprehensive mechanism of Schisandra chinensis polysaccharides mitigating Alzheimer's disease in rats using a UPLC-Q-TOF-MS …

J Fu, J Li, Y Sun, S Liu, F Song, Z Liu - Food & Function, 2023 - pubs.rsc.org
As a well-known traditional Chinese medicine and functional food, Schisandra chinensis (S.
chinensis) has been proved to possess excellent neuroprotective effects, and particularly the …

[HTML][HTML] Is fat the future for saving sight? Bioactive lipids and their impact on glaucoma

M Kolko, ZA Mouhammad, B Cvenkel - Pharmacology & Therapeutics, 2023 - Elsevier
Glaucoma is characterized by a continuous loss of retinal ganglion cells. The cause of
glaucoma is associated with an increase in intraocular pressure (IOP), but the underlying …

[HTML][HTML] Marine fish-derived lysophosphatidylcholine: Properties, extraction, quantification, and brain health application

MK Ahmmed, M Hachem, F Ahmmed, A Rashidinejad… - Molecules, 2023 - mdpi.com
Long-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are
the most bioavailable omega-3 fatty acid form and are considered important for brain health …

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

K Sánchez‐Alegría, C Arias - Endocrinology, Diabetes & …, 2023 - Wiley Online Library
Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets
(HFDs), and high consumption has been associated with the development of insulin …

[HTML][HTML] Lysophosphatidylcholine-DHA Specifically Induces Cytotoxic Effects of the MDA-MB-231 Human Breast Cancer Cell Line In Vitro—Comparative Effects with …

D Mohamad Ali, K Hogeveen, RM Orhant… - Nutrients, 2023 - mdpi.com
Docosahexaenoic acid (DHA, C22: 6 ω-3) is a dietary polyunsaturated fatty acid that has an
important role in human health. Epidemiological studies linked a high intake of DHA to a …

[HTML][HTML] Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases

A Lo Van, N Bernoud-Hubac, M Lagarde - Nutrients, 2022 - mdpi.com
Docosahexaenoic acid-containing lysophosphatidylcholine (DHA-LysoPC) is presented as
the main transporter of DHA from blood plasma to the brain. This is related to the major …

[HTML][HTML] Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders

T Karaki, H Haniu, Y Matsuda, T Tsukahara - Biomedicines, 2022 - mdpi.com
Neurodegenerative diseases (NDs) commonly present misfolded and aggregated proteins.
Considerable research has been performed to unearth the molecular processes …