Malignant gliomas are the most frequently occurring, devastating primary brain tumors, and
are coupled with a poor survival rate. Despite the fact that complete neurosurgical resection …

Exposure of tumours to anti‐cancer drugs, gene or radiation therapy consistently leads to an
increase in water diffusion in the cases expressing favourable treatment response. The …

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses
for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work …

Malignant glioma is a devastating brain tumor with no effective treatment. This randomised,
controlled study involved 36 patients with operable primary or recurrent malignant glioma …

Flexible alteration of virus surface properties would be beneficial for enhanced and targeted
gene delivery. A useful approach could be based on a high-affinity receptor–ligand pair …

Alpha-herpesvirus thymidine kinase (TK) genes are virulence-related genes and are
nonessential for viral replication; they are often preferred target genes for the construction of …

Gene therapy is defined as a technology that aims to modify the genetic component of cells
to gain therapeutic benefits. Suicide gene therapy (or gene-directed enzyme prodrug …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. Despite current treatment modalities, such as surgical resection followed by …

Retrovirus (RV) has been one of the earliest recombinant vectors to be investigated in the
context of cancer gene therapy. Experiments in cell culture and in animal brain tumor …

Pseudotyping of viral vectors has been widely used to enhance viral transduction efficiency.
One of the most popular pseudotyping proteins has been the G-protein of the Vesicular …