Biomechanical testing methodologies for the spine have developed over the past 50 years.
During that time, there have been several paradigm shifts with respect to techniques. These …

Plants are frequently exposed to one or more abiotic stresses, including combined salinity-
drought, which significantly lowers plant growth. Many studies have been conducted to …

Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …

Circadian clocks in the brain and peripheral tissues temporally coordinate local physiology
to align with the 24 hours rhythmic environment through light/darkness, rest/activity and …

Low back pain is the leading cause of disability worldwide and in many patients the source
of pain can be attributed to pathological changes within the intervertebral disc (IVD). As …

A comprehensive understanding of multiscale and multiphasic intervertebral disc mechanics
is crucial for designing advanced tissue engineered structures aiming to recapitulate native …

Intervertebral disc degeneration (IDD)-induced low back pain significantly influences the
quality of life, placing a burden on public health systems worldwide. Currently available …

Bovine caudal discs have been widely used in spine research due to their increased
availability, large size, and mechanical and biochemical properties that are comparable to …

The high water content of the intervertebral disc is essential to its load bearing function and
viscoelastic mechanical behavior. One of the primary biochemical changes associated with …

The mechanical behaviour of the intervertebral disc highly depends on the content and
transport of interstitial fluid. It is unknown, however, to what extent the time-dependent …