2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery
due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics …

Abstract Phosphodiesterase 7 (PDE7) specifically hydrolyzes cyclic adenosine
monophosphate (cAMP), a second messenger that plays essential roles in cell signaling …

An iron/chromium system (Fe (OAc) 2, CpCr (CO) 3H) catalyzes the preparation of β, γ-or γ,
δ-unsaturated amides from 1, 4, 2-dioxazol-5-ones. An acyl nitrenoid iron complex seems …

We report a practical, light-mediated perfluoroalkylation using Langlois' reagent (sodium
trifluoromethylsulfinate) that proceeds in the absence of any photocatalyst or additives. This …

Traditional liquid-phase extraction procedures are against the principles of green chemistry.
Therefore, it is important to develop eco-friendly procedures. In this study, an in-syringe …

Computational investigation at the BHandHLYP/6-311+ G (d, p) level of theory of the gas-
phase tautomerism of 2-and 4-pyridones confirmed the slight prevalence of lactim in the …

A practical and regioselective direct N-alkylation of 2-pyridones is enabled by use of α-keto
esters in the P (NMe2) 3-mediated deoxygenation process. The reaction proceeds under …

Here we report a palladium-catalyzed anti-Michael-type hydroamination of N-(quinolin-8-yl)
acrylamide with 2-pyridones. The use of a palladium catalyst enables the α-addition of 2 …

Chemodivergent construction of structurally distinct heterocycles from the same precursors
by adjusting specific reaction parameters is an emergent area of organic synthesis; yet …

Aziridine had different regioselective ring openings depending on the functional group of its
alkyl substituent. In the case of the alkyl group bearing γ-ketone at the C2 substituent of …