Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …

Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …

In recent years, biomarkers have been integrated into the diagnostic process and have
become increasingly indispensable for obtaining knowledge of the neurodegenerative …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial
pathological events or factors that cause progressive neuronal loss, and cognitive …