The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken - Nature Reviews Immunology, 2018 - nature.com
T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
The diverse function of PD-1/PD-L pathway beyond cancer
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
Tim‐3 and its role in regulating anti‐tumor immunity
M Das, C Zhu, VK Kuchroo - Immunological reviews, 2017 - Wiley Online Library
Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
L Cherkassky, A Morello… - The Journal of …, 2016 - Am Soc Clin Investig
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory
receptors on T cells. This adaptive resistance compromises the efficacy of chimeric antigen …
receptors on T cells. This adaptive resistance compromises the efficacy of chimeric antigen …
Mouse models in oncoimmunology
L Zitvogel, JM Pitt, R Daillère, MJ Smyth… - Nature Reviews …, 2016 - nature.com
Fundamental cancer research and the development of efficacious antineoplastic treatments
both rely on experimental systems in which the relationship between malignant cells and …
both rely on experimental systems in which the relationship between malignant cells and …
Exosomes as smart drug delivery vehicles for cancer immunotherapy
H Zhang, S Wang, M Sun, Y Cui, J Xing… - Frontiers in …, 2023 - frontiersin.org
Exosomes (Exos) as drug delivery vehicles have been widely used for cancer
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …
Liposome-based drug co-delivery systems in cancer cells
Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
J Galon, D Bruni - Nature reviews Drug discovery, 2019 - nature.com
Immunotherapies are the most rapidly growing drug class and have a major impact in
oncology and on human health. It is increasingly clear that the effectiveness of …
oncology and on human health. It is increasingly clear that the effectiveness of …
Molecular and cellular mechanisms underlying brain metastasis of breast cancer
M Hosonaga, H Saya, Y Arima - Cancer and Metastasis Reviews, 2020 - Springer
Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …
Treatment strategies and metabolic pathway regulation in urothelial cell carcinoma: a comprehensive review
For a long time, cisplatin-based chemotherapy had been viewed as first-line chemotherapy
for advanced and metastatic urothelial carcinoma (UC). However, many patients with UC …
for advanced and metastatic urothelial carcinoma (UC). However, many patients with UC …