The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …

Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …

The past decade has seen tremendous development in digital health, including in innovative
new technologies such as Electronic Health Records, telemedicine, virtual visits, wearable …

From the introduction of hyperferritinemic syndrome concept, a growing body of evidence
has suggested the role of ferritin as a pathogenic mediator and a relevant clinical feature in …

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by
thrombosis and pregnancy morbidity with the persistent presence of antiphospholipid …

Abstract Treat-to-target (T2T) is currently the most fashionable strategy for treatment-naïve,
early rheumatoid arthritis (RA) patients. A T2T approach can lead to a complete and drug …

Multiple lines of evidence have increasingly suggested a pathogenic connection between
rheumatoid arthritis (RA) and the mechanisms of type 2 diabetes (T2D) in a vicious circle …

In the last ten years, many advances have been made in the treatment and diagnosis of
immune-mediated diseases. In particular, an increasing number of new monoclonal …

The global rise of prediabetes and diabetes has spawned an epidemic of complications
associated with these conditions. Neuropathy is the most common consequence, with distal …