A brief overview of the cerebrospinal fluid system and its implications for brain and spinal cord diseases

TO Wichmann, HH Damkier… - Frontiers in human …, 2022 - frontiersin.org
A comprehensive understanding of the cerebrospinal fluid (CSF) system is essential for our
understanding of health and disease within the central nervous system (CNS). The system of …

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

JK Karimy, BC Reeves, E Damisah, PQ Duy… - Nature Reviews …, 2020 - nature.com
Hydrocephalus is the most common neurosurgical disorder worldwide and is characterized
by enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles resulting from failed …

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

JK Karimy, J Zhang, DB Kurland, BC Theriault… - Nature medicine, 2017 - nature.com
The choroid plexus epithelium (CPE) secretes higher volumes of fluid (cerebrospinal fluid,
CSF) than any other epithelium and simultaneously functions as the blood–CSF barrier to …

From stroke to dementia: a comprehensive review exposing tight interactions between stroke and amyloid-β formation

R Goulay, L Mena Romo, EM Hol… - Translational Stroke …, 2020 - Springer
Stroke and Alzheimer's disease (AD) are cerebral pathologies with high socioeconomic
impact that can occur together and mutually interact. Vascular factors predisposing to …

The regulatory roles of motile cilia in CSF circulation and hydrocephalus

V Kumar, Z Umair, S Kumar, RS Goutam, S Park… - Fluids and Barriers of …, 2021 - Springer
Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates
within brain spaces like the ventricular cavities, subarachnoid space, and the spine. Its …

Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

SD Lolansen, N Rostgaard, D Barbuskaite… - Fluids and barriers of the …, 2022 - Springer
Introduction Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic
events such as intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH) …

Paediatric hydrocephalus

KT Kahle, PM Klinge, JE Koschnitzky… - Nature Reviews …, 2024 - nature.com
Hydrocephalus is classically considered as a failure of cerebrospinal fluid (CSF)
homeostasis that results in the active expansion of the cerebral ventricles. Infants with …

Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

TL Toft-Bertelsen, D Barbuskaite, EK Heerfordt… - Fluids and barriers of the …, 2022 - Springer
Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: from normal physiology to pathophysiological changes

Y Fang, L Huang, X Wang, X Si… - Journal of Cerebral …, 2022 - journals.sagepub.com
Knowledge about the dynamic metabolism and function of cerebrospinal fluid (CSF)
physiology has rapidly progressed in recent decades. It has traditionally been suggested …

[HTML][HTML] Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep

J Benavides-Lara, R Manwar, LS McGuire, MT Islam… - Photoacoustics, 2023 - Elsevier
Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are
common because the periventricular blood vessels are still developing up to 36 weeks and …