Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …

Biomarkers for urinary tract infection: present and future perspectives

TK Mattoo, JD Spencer - Pediatric Nephrology, 2024 - Springer
A prompt diagnosis of urinary tract infection (UTI) is necessary to minimize its symptoms and
limit sequelae. The current UTI screening by urine test strip analysis and microscopic …

Antimicrobial Agent Functional Gold Nanocluster-Mediated Multichannel Sensor Array for Bacteria Sensing

Y Xiao, P Cheng, X Zhu, M Xu, M Liu, H Li, Y Zhang… - Langmuir, 2024 - ACS Publications
Urinary tract infections (UTIs) have greatly affected human health in recent years. Accurate
and rapid diagnosis of UTIs can enable a more effective treatment. Herein, we developed a …

Insulin receptor orchestrates kidney antibacterial defenses

L Schwartz, A Simoni, P Yan, K Salamon… - Proceedings of the …, 2024 - pnas.org
Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection
risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct …

Iron limitation induces motility in uropathogenic E. coli CFT073 partially through action of LpdA

AE Frick-Cheng, AE Shea, JR Roberts, SN Smith… - Mbio, 2024 - Am Soc Microbiol
More than half of women will experience a urinary tract infection (UTI) with most cases
caused by uropathogenic Escherichia coli (UPEC). Bacterial swimming motility enhances …

Human ribonuclease 6 has a protective role during experimental urinary tract infection

JD Ruiz-Rosado, H Cortado, M Kercsmar, B Li… - Journal of Innate …, 2023 - karger.com
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to
the RNase A superfamily have a critical role in defending the bladder and kidney from …

[HTML][HTML] Murine Ribonuclease 6 Limits Bacterial Dissemination during Experimental Urinary Tract Infection

H Cortado, M Kercsmar, B Li… - Journal of Innate …, 2024 - karger.com
Abstract Introduction: The ribonuclease (RNase) A superfamily encodes cationic
antimicrobial proteins with potent microbicidal activity toward uropathogenic bacteria …

Current and emerging strategies to curb antibiotic-resistant urinary tract infections

A Simoni, L Schwartz, GY Junquera, CB Ching… - Nature Reviews …, 2024 - nature.com
Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes
and prolong hospital stays. Consequently, new strategies are needed to prevent and control …

High Incidence of Antibiotic Resistance in the Uropathogenic Bacteria Associated with Different Urological Diseases and Metabolic Complications: A Single Center …

Y Subramaniyan, A Khan… - Microbial Drug …, 2024 - liebertpub.com
Urological diseases affect all age groups and are associated with different urinary
complications. Presence of pathogenic bacteria complicates the urological diseases such as …

DEFA1A3 DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection

JJ Canas, SW Arregui, S Zhang, T Knox… - Life Science …, 2024 - life-science-alliance.org
Antimicrobial peptides (AMPs) are host defense effectors with potent neutralizing and
immunomodulatory functions against invasive pathogens. The AMPs α-Defensin 1 …