Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Highlights•Copper and iron play key roles in the virulence of Cryptococcus
neoformans.•Metals influence the cell wall, melanin formation, and capsule elaboration.•The …

Cryptococcus neoformans causes life-threatening pneumonia and meningitis and is
regarded as one of the leading killers of immunocompromised individuals. There is currently …

Antifungal therapy, especially with the azoles, could promote the incidence of less
susceptible isolates of Cryptococcus neoformans and C. gattii species complexes (SC) …

Cryptococcus neoformans infections are a major worldwide concern as current treatment
strategies are becoming less effective in alleviating the infection. The most extreme and fatal …

The importance of humoral immunity to fungal infections remains to be elucidated. In
cryptococcosis, patients that fail to generate antibodies against antigens of the fungus …