Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of
muscle loss that occurs in the elderly. Since then, a broader definition comprising not only …

Regular screening for the early detection of common chronic diseases might benefit from the
use of deep-learning approaches, particularly in resource-poor or remote settings. Here we …

Advances in our understanding of uremic retention solutes, and improvements in
hemodialysis membranes and other techniques designed to remove uremic retention …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

Under normal conditions, inflammation is a protective and physiological response to various
harmful stimuli. However, in several chronic debilitating disorders, such as chronic kidney …

Heart failure (HF) is a major health-care problem and the prognosis of affected patients is
poor. HF often coexists with a number of comorbidities of which declining renal function is of …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …