[HTML][HTML] Clinical trials in vascular cognitive impairment following SPRINT-MIND: an international perspective
A large interventional trial, the Systolic Blood Pressure Intervention Trial sub-study termed
Memory and Cognition in Decreased Hypertension (SPRINT-MIND), found reduced risk of …
Memory and Cognition in Decreased Hypertension (SPRINT-MIND), found reduced risk of …
Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline
Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease
pathophysiology and progression toward dementia. Cerebral amyloid angiopathy is a form …
pathophysiology and progression toward dementia. Cerebral amyloid angiopathy is a form …
[HTML][HTML] Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy?
R Tarawneh - Biomolecules, 2023 - mdpi.com
Alzheimer disease (AD) models are based on the notion that abnormal protein aggregation
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …
Vascular burden and cognition: mediating roles of neurodegeneration and amyloid PET
It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …
[HTML][HTML] Mediterranean diet and white matter hyperintensity change over time in cognitively intact adults
Current evidence on the impact of Mediterranean diet (MeDi) on white matter hyperintensity
(WMH) trajectory is scarce. This study aims to examine whether greater adherence to MeDi …
(WMH) trajectory is scarce. This study aims to examine whether greater adherence to MeDi …
[HTML][HTML] Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults
White matter hyperintensities are a marker of small vessel cerebrovascular disease that are
strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well …
strongly related to cognition in older adults. Similarly, medial temporal lobe atrophy is well …
[HTML][HTML] Physical activity moderates the association between white matter hyperintensity burden and cognitive change
Objective Greater physical activity (PA) could delay cognitive decline, yet the underlying
mechanisms remain unclear. White matter hyperintensity (WMH) burden is one of the key …
mechanisms remain unclear. White matter hyperintensity (WMH) burden is one of the key …
[HTML][HTML] Research progress on MRI for white matter hyperintensity of presumed vascular origin and cognitive impairment
F Meng, Y Yang, G Jin - Frontiers in Neurology, 2022 - frontiersin.org
White matter hyperintensity of presumed vascular origin (WMH) is a common medical
imaging manifestation in the brains of middle-aged and elderly individuals. WMH can lead to …
imaging manifestation in the brains of middle-aged and elderly individuals. WMH can lead to …
Longitudinal relationships of white matter hyperintensities and alzheimer disease biomarkers across the adult life span
J Luo, Y Ma, FJ Agboola, E Grant, JC Morris… - Neurology, 2023 - AAN Enterprises
Background and Objectives White matter hyperintensities (WMH) correlate with Alzheimer
disease (AD) biomarkers cross-sectionally and modulate AD pathogenesis. Longitudinal …
disease (AD) biomarkers cross-sectionally and modulate AD pathogenesis. Longitudinal …
Differential effects of white matter hyperintensities and regional amyloid deposition on regional cortical thickness
White matter hyperintensities (WMH) and β-amyloid (Aβ) accumulation have both been
linked to neurodegeneration in Alzheimer's disease (AD). However, the independent effects …
linked to neurodegeneration in Alzheimer's disease (AD). However, the independent effects …