Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the
prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D has almost …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

The distinction between innate and adaptive immunity is one of the basic tenets of
immunology. The co-operation between these two arms of the immune system is a major …

Failures of highly touted trials have caused experts to call for re-evaluation of the current
approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy …

Emerged evidence has indicated that immunosuppression is involved in the occurrence and
development of sepsis. To provide clinical practice recommendations on the immune …