Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

Background The apparent disconnection between biological complexity and both genome
size (C-value) and gene number (G-value) is one of the long-standing biological puzzles …

Simple Summary DNA structural biology deals with the understanding of DNA and three-
dimensional chromatin structure, which can determine its function in the cell. The key …

The chromatin of the human genome was analyzed at three DNA size levels. At the first,
compartment level, two “gene spaces” were found many years ago: A GC-rich, gene-rich …

The Japanese wrinkled frog (Glandirana rugosa) is unique in having both XX-XY and ZZ-ZW
types of sex chromosomes within the species. The genome sequencing and comparative …

Widespread horizontal gene transfer (HGT) may appear a significant factor that accelerates
biological evolution. Here we look at HGT primarily from the point of view of prokaryote …

Simple Summary Eukaryotic genes are organized as DNA sequences containing exon and
intron regions. Exons relate to sequences that, after transcription, will be maintained in …

The most significant genetic influence on eye color pigmentation is attributed to the intronic
SNP rs12913832 in the HERC2 gene, which interacts with the promoter region of the …

Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies
of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever …

Genomes are characterized by large regions of homogeneous base compositions known as
isochores. The latter are divided into GC-poor and GC-rich classes linked to distinct …