Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …

WHEN chondrocytes from sternal or articular cartilage are kept in monolayer culture at low
density, they eventually lose their cartilage phenotype1–4. Within four passages or …

Table of contents: I. Structure and function of joints, connective tissue, and muscle. II.
Immune and inflammatory responses. III. Evaluation of the patient. IV. Special issues of the …

Collagen phenotypes were determined for rabbit articular chondrocytes in cartilage slices
and first through fifth monolayer cultures. During the first 24 hr of slice culture, chondrocytes …

Objective. To investigate the appearance of hypertrophic chondrocytes in osteoarthritic (OA)
cartilage, using type X collagen as a specific marker. Methods. The biosynthesis of type X …

Intensive research in the last decade has revealed a wealth of detail on the mechanism of
biosynthesis, molecular structure, and covalent cross-linking of collagen. Tissues of higher …

Collagen is the single most abundant animal protein in mammals accounting for about 30%
of all proteins. The collagen molecules, after being secreted by the cells, assemble into …

ARTICULATING JOINTS BETWEEN bones of the vertebrate skeleton are classified into two
major categories, diarthroses and amphiarthroses. The diarthroses are freely mobile and …

Normal and osteoarthritic human articular cartilage was investigated by in situ hybridization
for expression patterns of the fibrillar collagens type I, II, and III to evaluate phenotypic …