It is generally held that the role of a specific control element can only be understood within
its physiological environment. The reviewed studies make it clear that there is a potent …

One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to
the peripheral circulation and to the heart. A correlation between plasma norepinephrine …

To elucidate the time course of sympathovagal balance and its relationship to left ventricular
function in heart failure, we serially evaluated left ventricular contractility and relaxation and …

Objectives. This study evaluated the effect of digoxin on cardiac sympathetic activity in
patients with congestive heart failure. Background. Digoxin favorably alters autonomic tone …

We investigated to what extent heart failure alters the ability of the muscle metaboreflex to
improve ventricular function. Dogs were chronically instrumented to monitor mean arterial …

Circulation Journal Vol. 75, February 2011 characterized by many features that resemble
human congestive HF (Table). Of note, after a few weeks of rapid pacing, LV systolic …

This brief review summarizes recent studies describing the potential role of the muscle
metaboreflex in mediating the altered cardiovascular responses to dynamic exercise in heart …

Objectives: We examined the effects of chronic type A endothelin receptor (ETA) blockade in
a dog model of pacing-induced cardiomyopathy. Methods: Eight dogs received an ETA …

Brändle, Marian, Kaushik P. Patel, Wei Wang, and Irving H. Zucker. Hemodynamic and
norepinephrine responses to pacing-induced heart failure in conscious sinoaortic …

BACKGROUND: The mechanisms of cardiac remodeling during chronic heart failure remain
poorly defined. We sought to advance a chronic canine model of nonischemic …