Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …

Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

Polymer-based solid dispersions including amorphous solid dispersions (ASD) are viable
strategies to enhance the release of poorly soluble drugs. The concurrency of the drug and …

Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …

Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous
processing technology, used to design custom products by co-processing drugs together …

Abstract Forty-eight (48) drug products (DPs) containing amorphous solid dispersions
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …

Amorphous solid dispersion (ASD) has been widely used to enhance the oral bioavailability
of water-insoluble drugs for oral delivery because of its advantages of enhancing solubility …

Amorphous solid dispersions (ASD) are one of the most prominent formulation approaches
to overcome bioavailability issues that are often presented by new poorly soluble drug …

The success of obtaining solid dispersions for solubility improvement invariably depends on
the miscibility of the drug and polymeric carriers. This study aimed to categorize and select …