Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …

The interaction disorder between gut microbiota and its host has been documented in
different non-communicable diseases (NCDs) such as metabolic syndrome …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …

In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …

Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding
condition, retinitis pigmentosa (RP). Over 150 different mutations in rhodopsin have been …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …