Interaction between hyaluronic acid (HA) and CD44 has been considered a key event in
tumor invasion and metastasis. HA is a linear, high molecular weight glycosaminoglycan in …

CD44 is important during myelopoiesis, although the contributions of variant CD44 proteins
are unclear. We show here that in human long-term bone marrow culture antibodies …

Previous findings from our laboratory demonstrated that when used at low concentration (0.1
μg ml− 1), CsA as well as its analog PSC 833 were able to revert the MDR phenotype, while …

Interactions of tumor cells with the endothelium and tissue stroma are considered to be
critical steps in metastasis formation and progression of cancer. To identify cellular receptors …

To analyze the role of alpha4-integrins in lymphoma metastasis, sublines of the T-cell
lymphoma LB were generated by retrovirus-mediated gene transfer that differ exclusively in …

Among the mechanisms that induce multidrug resistance (MDR), one of those most frequent
is over-expression of a phosphoglycoprotein (Pgp) encoded in the mouse by the mdr-1 and …

The key effector proteins of apoptosis are a family of cysteine proteases termed caspases.
Following activation of caspases, biochemical events occur that lead to DNA degradation …

Migration of some tumor cells, and their lodgment in target organs, is dependent on the
activation of cell surface CD44 receptor, usually detected by its ability to bind hyaluronic acid …

The in vitro proliferation of the spontaneous lymphoid T‐cell leukemia designated LB was
enhanced by physiological, intermediate and supraphysiological concentrations of insulin …

Cancer cells may frequently develop cross-resistance to structurally dissimilar
chemotherapeutic agents. However, the molecular mechanisms for sensitivity and …