Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

The activation of STING in cancer cells is conducive to inducing apoptosis of cancer cells
and activating immune responses for immunotherapy by improving antigen presentation …

Hepatitis B virus (HBV) is a major cause of chronic hepatitis, liver cirrhosis, and
hepatocellular carcinoma. Despite the advent of vaccines and potent antiviral agents able to …

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is
characterized by alterations of the mitochondrial DNA, reduced respiratory capacity …

Targeted manipulation of cytoplasmic double-strand (dsDNA) generation in tumors to
activate cGAS-STING signaling remains challenging in antitumor immunity. Herein, we …

Host-microbe interactions influence intestinal stem cell (ISC) activity to modulate epithelial
turnover and composition. Here, we investigated the functional impacts of viral infection on …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients
with immunologically “cold” tumors devoid of tumor-infiltrating lymphocytes (TILs). We found …

Protein knockdown with an inducible degradation system is a powerful tool for studying
proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) …

In the realm of cancer treatment, traditional modalities like radiotherapy and chemotherapy
have achieved certain advancements but continue to grapple with challenges including …