Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Several commonly prescribed antiepileptic drugs (AEDs)—including phenobarbital,
phenytoin, and carbamazepine—stimulate the synthesis of a broad range of …

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

In the past decade, many tyrosine-kinase inhibitors have been introduced in oncology and
haemato-oncology. Because this new class of drugs is extensively used, serious drug–drug …

PURPOSE Phosphatidylinositol 3-kinase (PI3K) signaling is highly active in glioblastomas.
We assessed pharmacokinetics, pharmacodynamics, and efficacy of the pan-PI3K inhibitor …

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …

EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein
product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes …

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one
of the most aggressive cancers in man. Despite technological advances in surgical …